Doxycycline hyclate is used in tetracycline (doxycycline)-inducible gene expression as a stable switch to control transcriptional activation. This system is also known as the Tet-On/Tet-Off system with doxycycline-sensitive GMO mice.
Code | Diets | Advantages | Daily intake mg/kg BW * |
---|---|---|---|
E8200 Version 0092 | A03 at 0.2g/Kg Doxycycline Hyclate |
Standard diet
| 32 |
E8200 Version 0115 | A03 at 0.625g/Kg Doxycycline Hyclate | Standard diet | 100 |
E8200 Version 0001 | A03 at 1g/Kg Doxycycline Hyclate | Standard diet | 160 |
E8200 Version 0100 | A03 at 10g/Kg Doxycycline Hyclate |
Standard diet
| 1600 |
E8404 Version 0010 | 150 at 0.2g/Kg Doxycycline Hyclate | Soya and alfalfa free | 32 |
E8404 Version 0002 | 150 at 0.625g/Kg Doxycycline Hyclate |
Soya and alfalfa free
| 100 |
Code | Diets | Advantages | Daily intake mg/kg BW * |
---|---|---|---|
E8404 Version 0011 | 150 at 1g/Kg Doxycycline Hyclate |
Soya and alfalfa free
| 160 |
E8404 Version 0012 | 150 at 10g/Kg Doxycycline Hyclate | Soya and alfalfa free | 1600 |
U8978 Version 0058 | AIN 93-G at 0.2g/Kg Doxycycline Hyclate | Purified diet | 32 |
U8978 Version 0059 | AIN 93-G at 0.625g/Kg Doxycycline Hyclate |
Purified diet
| 100 |
U8978 Version 0060 | AIN 93-G at 1g/Kg Doxycycline Hyclate | Purified diet | 160 |
U8978 Version 0061 | AIN 93-G at 10g/Kg Doxycycline Hyclate |
Purified diet
| 1600 |
* Daily intake mg per kg body weight assumes 20-25 g body weight and 3-4 g intake.
Since tetracycline and doxycycline are photosensitive, the use of amber water bottles is recommended for administration in water. Further disadvantages include the risk of dehydration (molecular taste) and the need to use sucrose for better acceptance.
The doxycycline is a light sensible ingredient. The pelleted doxycycline diet reduces exposure to light and guarantees better stability due to the much lower degradation rate of doxycycline hyclate.
Dosage via | Advantages | Disadvantages |
---|---|---|
Custom diet | Not stressful for the animals |
Dose depends on feed intake |
Drinking water | Not stressful for the animals |
Tetracycline and doxycycline are light sensitive |
Intraperitoneal Injection (IP) | Reliable dosage, especially for very sick animals |
Stressful for the animals |
To guarantee a extended 6 months shelf life our doxycycline diets are produced on customer request. Beside that, it is also possible to choose the base diet, concentration of doxycycline hyclate and the food color according to your specific needs. If your process requires fluorescent imaging, we recommend using a purified diet to improve the quality of the imaging.
SAFE® customizes diets with tamoxifen to activate CreER. The site-specific Cre/lox recombination system has been proven to generate conditional somatic GMOs in mice. This method allows to spatially and temporally control gene activity in almost any mouse tissue.
To move, grow and reproduce, animals consume energy. Their needs are very different and energy consumption also varies. To anticipate or respond to these needs, some animals store energy, while others prefer to increase the amount of food they consume or digest food more efficiently.